The Tylenol is much more toxic than the codeine in the medication. You would die from liver damage before you would die from lack of breathing/heart function and CNS (central nervous system) depression from the codeine. So, follow the protocol for Tylenol toxicity and maximum daily dosage. That is, no more than 4000mg, or 4 grams, of Tylenol when taking the medication short term. In extra strength Tylenol, this equates to 8 tablets. You should never take more than 1000mg, or 1 gram, (2 tablets of extra strength Tylenol) in a 4 hour period.
If you're taking the medication for chronic or long-term treatment (continuously for 2 weeks or more), 2500mg per day is the rule of thumb. Anything over that and you're at risk for liver damage. Alcohol consumption, of course, (as well as intake of several other substances) increases the likelihood of liver damage and lowers the threshold of the amount of Tylenol required to cause liver damage and failure.
Liver failure from Tylenol is not sudden nor immediate. It happens slowly and often unnoticeably before it's too late. I don't think I need to say that getting a liver transplant for a liver that you damaged yourself and avoidably so is very difficult as "supplies" are limited and reserved for those who have a failing liver though no fault of their own.
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