How many 4 number combinations are there with 16 numbers?

To calculate the number of 4-number combinations possible with 16 numbers, you would use the formula for combinations, which is nCr = n! / r!(n-r)!. In this case, n = 16 (the total number of numbers) and r = 4 (the number of numbers in each combination). Plugging these values into the formula, you would calculate 16C4 = 16! / 4!(16-4)! = 1820. Therefore, there are 1820 possible 4-number combinations with 16 numbers.