Yes, you can close a drawing in AutoCAD 2010 even if a command is active. To do this, you can simply click the "X" button in the upper right corner of the drawing window or use the "File" menu to select "Close." If prompted to save changes to the drawing, you can choose to save, discard, or cancel based on your preference. However, it's generally a good practice to complete or cancel the active command to avoid any potential loss of work.
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