To fix the ESP malfunction on a 2006 E350, first check for any trouble codes using an OBD-II scanner, which can help identify the specific issue. Common fixes include inspecting and replacing faulty wheel speed sensors, checking the brake fluid level, and ensuring the ABS module is functioning properly. If the problem persists, consider resetting the system by disconnecting the battery for a few minutes, or consult a professional mechanic for further diagnosis and repair.
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