Charles V's domestic policy primarily focused on maintaining the unity and stability of his vast empire, which included Spain, the Holy Roman Empire, and various Italian territories. He sought to enforce Catholic orthodoxy and combat the Protestant Reformation, often resorting to harsh measures against dissenters. Additionally, he aimed to strengthen the central authority of the monarchy, manage regional conflicts, and promote economic development within his realms. His policies ultimately faced challenges from both religious strife and regional autonomy movements.
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