A pistol squat primarily targets the quadriceps, glutes, and core muscles, while a barbell squat engages a wider range of muscles including the back and shoulders. Pistol squats require more balance and stability due to being a single-leg exercise, while barbell squats provide more stability with the use of both legs. Both exercises are effective for strength training, but barbell squats are generally considered more efficient for overall muscle development and strength gains.
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