If the fan clutch on your Lexus LS 400 locks up, the engine's cooling fan will run continuously at full speed, regardless of the engine temperature. This can lead to excessive engine noise, increased wear on the fan and its bearings, and potential overheating if the fan does not engage properly. Additionally, it may cause a decrease in fuel efficiency and could lead to premature failure of other cooling system components. It's advisable to have it inspected and replaced if necessary.
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