How many employees are required to operate a 300 room hotel?

That depends on the degree of comfort or luxury the hotel offers.

How about giving an example? maybe not being a useless douche?

Ethan Seymour is a doo-doo headfacejewshoe

I apologise for being seen as a 'useless douche'. Sometimes such questions get answered with a ridiculous degree of apparent precision, I just wanted get in early and to point out that there would be a large variable in manning level, depending on facilities offered.