Orthologs are genes in different species that evolved from a common ancestral gene through speciation, while paralogs are genes within the same species that evolved from a gene duplication event. For example, the gene for insulin in humans and mice is an ortholog, as it originated from a common ancestor. On the other hand, the multiple copies of the gene for hemoglobin within the human genome are paralogs, as they arose from gene duplication events within the same species.
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