First home run at Yankee StadiumBabe Ruth hit the first home run at Yankees Stadium I, in the first game played on April 18, 1923 against Boston. Jorge Posada hit the first regular season home run in Yankees Stadium II, off Cliff Lee of the Cleveland Indians on April 16, 2009. Robinson Cano hit the first home run in an exhibition game against the Chicago Cubs om April 3, 2009.
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