What is wrong with a person who has sickle-cell anemia?

Sickle-cell anemia is a genetic disorder that affects the shape and function of red blood cells. In affected individuals, hemoglobin, the protein that carries oxygen, is abnormal, causing red blood cells to become rigid and crescent-shaped. This abnormal shape leads to blockages in blood vessels, resulting in pain, increased risk of infections, and potential organ damage due to reduced blood flow and oxygen supply. Additionally, these sickle-shaped cells have a shorter lifespan, leading to chronic anemia.