Can you take 500g flucloxacillin and 500g co-codamol together?

Taking 500g of flucloxacillin and 500g of co-codamol together is not advisable and could be dangerous. The dosages you're mentioning are excessively high; typical doses for flucloxacillin are in the range of 250-500 mg, and for co-codamol, it is usually 8/500 mg or 30/500 mg. Always consult a healthcare professional before combining medications to avoid serious side effects or interactions.