Which structures of the body deteriorate during Parkinson and disease?

In Parkinson's disease, the primary structures that deteriorate are the dopaminergic neurons in the substantia nigra, a region of the brain responsible for movement control. This loss of neurons leads to a significant decrease in dopamine production, resulting in the characteristic motor symptoms of the disease, such as tremors, rigidity, and bradykinesia. Additionally, other brain areas, including the striatum and the locus coeruleus, may also experience neurodegeneration, contributing to both motor and non-motor symptoms.