If globe valve is installed in reverse direction is there any change in pressure drop?

Yes, if a globe valve is installed in the reverse direction, there can be a change in pressure drop across the valve. Globe valves are designed to control flow in a specific direction, and reversing them can lead to increased turbulence and flow resistance. This may result in a higher pressure drop compared to correct installation, potentially affecting system performance. Additionally, it may cause operational issues such as improper sealing and increased wear.