Will acetaminophen give you a buzz?

No, not really. If you take enough, you will begin to drool, and your stomach will begin to bleed. It will reduce sensation and brain function in your body, and if you don't throw up or pass out, you will have a severe headache and/or other pains. These effects require about 2000 milligrams (10 standard pills) to be taken at a time, at the lowest.