Yes, Lyme disease can recur, but this typically occurs in two ways: through reinfection with the bacteria Borrelia burgdorferi or as a result of lingering symptoms after initial treatment, known as post-treatment Lyme disease syndrome (PTLDS). Reinfection can happen if an individual is bitten by a tick carrying the bacteria again. PTLDS may cause persistent symptoms even after the infection has been treated, but it is not considered a true recurrence of the disease.
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