To disconnect a PICC line (peripherally inserted central catheter), first, perform hand hygiene and gather necessary supplies. Clamp the PICC line to prevent blood flow, then remove the cap from the connector, and clean the connector with an appropriate antiseptic. Gently pull the line out while stabilizing the catheter hub, then apply a sterile dressing to the site to prevent infection. Always follow your facility's protocols and guidelines for PICC line management.
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