Is marijuana an antagonist

THC, the primary active metabloite in Marijuana binds to the CB1 and CB2 receptors and is an agonist. It prompts the brain to release dopamine and endorphines into your brain, which get you high. Interstingly enough, cannabis contains another cannabinoid, cannbidiol, which acts as a partial agonist to the THC, blocking some of its effects but still letting it chill in your brain. As the cannabidiol is released from blocking the receptors, more THC is absorbed, keeping you high longer. Good cannabis contains around 18-22% THC and a good 35-40% cannbidiol.