What battle was general lee first defeat after this battle Lincoln issues emancipation proclamation?

General Robert E. Lee's first significant defeat came at the Battle of Antietam, which took place on September 17, 1862. This battle was particularly notable as it marked the end of Lee's first invasion of the North. Following the Union's strategic victory at Antietam, President Abraham Lincoln issued the Emancipation Proclamation on September 22, 1862, which declared the freedom of slaves in the Confederate states.