Has a wife of a us president ever died of cancer?

Yes, Two First Ladies Died Of Cancer, Pat Nixon Died In June 1993 0f Lung Cancer And Jacqueline Kennedy Died In May 1994 Of Lymphatic Cancer. Yes, Two First Ladies Died Of Cancer, Pat Nixon Died In June 1993 0f Lung Cancer And Jacqueline Kennedy Died In May 1994 Of Lymphatic Cancer.