Can cpt 99396 has a modifer 25?

Yes, CPT code 99396, which is used for a periodic comprehensive preventive medicine evaluation and management of an established patient, can have modifier 25 appended. Modifier 25 indicates that a significant, separately identifiable evaluation and management service was performed on the same day as the preventive service. This is applicable when the physician provides additional services beyond the routine preventive visit, justifying the use of both codes for billing.