What changed for the native Americans living in Florida during the 1500's?

During the 1500s, Native Americans in Florida experienced significant changes due to European exploration and colonization. The arrival of Spanish explorers, such as Juan Ponce de León in 1513, introduced new diseases that decimated indigenous populations, as they had no immunity. Additionally, European contact led to shifts in trade and social structures, as Native Americans were drawn into new economic systems and often faced violent encounters or displacement. These changes marked the beginning of profound disruptions in their traditional ways of life.