What can make the nucleolus more visible?

The nucleolus can become more visible through specific cellular activities, particularly during the active synthesis of ribosomal RNA (rRNA). Stimulation of cell growth or proliferation, such as during protein synthesis or in response to certain growth factors, can enhance nucleolar activity, making it more prominent. Additionally, certain staining techniques, like silver staining, can also highlight the nucleolus in microscopy, increasing its visibility in cellular studies.