United Kingdom
Yes, assuming the persons whose will it is has passed away you can create a deed of variation to alter your entitlement. Legal advice should be sought. In the UK, you can not create a deed of variation to deliberately avoid an increase in assets if you are receiving means tested or state benefits etc.
United States
Yes. The beneficiary can file a disclaimer with the court and give their inheritance back to the estate to be distributed as intestate property. This is often seen in estates in which priests and nuns have inherited a portion which they disclaim to be shared by their other siblings. An interest in real property must be clearly and specifically disposed of.
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