Salmonella faces several barriers in the body, including the acidic environment of the stomach, which can kill many bacteria. Additionally, the gut's epithelial cells and mucus layer provide physical barriers, while the immune system employs various defenses, such as phagocytes and antibodies, to recognize and eliminate the bacteria. Moreover, gut microbiota can compete with Salmonella for resources and space, further impeding its ability to establish infection.
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