No - Lamotrigine (Brand name Lamictal) is in a class of mood stabilizers. It's also used for epilepsy treatment. It has no MAO inhibitor effect. Lamotrigine has been shown to be a reversible inhibitor of MAO-A (Ki=15 uM) and MAO-B (Ki = 18 uM). MAO inhibition is possible at doses of 100-200mg/day and this could be a mechanism for the serotonin increases seen with lamotrigine treatment. The binding to the enzyme seems to be very reversible, that is, other MAO substrates can readily displace it. To the best of my knowledge, it lacks any clinically relevant interactions that are normally seen with MAOIs.
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