How long does it take for a prescription opioid to get in your bloodstream?

The immediate effects will typically wear off within a few hours. For purposes of testing, it may be a month or three. If a particular test utilized a sample of hair or nail, it is important to consider when the hair or nail sample formed which can be years ago. Some effects of opiate type drugs such as this can last for years and if prolonged or severe use has occurred, may last for life.