How many miles from middlesboro KY to frankfort KY?

About 155. This is the best route:

1. Take U.S. 25W NORTH to I-75 NORTH in Corbin.
2. Take I-75 NORTH to I-64 WEST to FRANKFORT and LOUISVILLE at EXIT 118 off I-64/75 near Lexington.
3. Continue WEST on I-64 to Frankfort.