What are 3 factors that determine sensitivity of target cells to hormones?

The sensitivity of target cells to hormones is influenced by the number of hormone receptors present on the cell surface, the affinity of these receptors for the hormone, and the presence of co-factors or second messengers that may amplify the hormone's effects. Additionally, the overall physiological state of the cell, including its metabolic activity and the presence of other signaling molecules, can also play a critical role in determining sensitivity. These factors collectively influence how effectively a hormone can bind to its receptor and elicit a response.