Can you take Zyrtec and advil cold and sinus?

Yes. Zyrtec is a 24 hour antihistamine which decreases the allergic response in your sinuses, lungs, eyes, skin, etc. Advil (ibuprofen) is a non-steroidal anti-inflammatory which must be taken every 6-8 hours and treats pain and inflammation through out your body. Some people should not take ibuprofen at all but there is no interaction between Zyrtec and Advil.