What different between 250 and 1000 thread count cotton?

The easy answer is 750. Thread count indicates the number of threads counted in one square inch of the fabric. 250 thread count fabric will be woven looser and feel rough to the touch in comparison to 1000 thread count fabric. Another difference is price. The higher the thread count the higher the price. According to Consumer Reports, anything over 400 thread count is a waste of money.