The Bible doesn't say exactly, but we can make an educated guess if we look at the years he was preaching.
He began his first missionary tour around 47-48 CE, and his third around 52-56 CE. He was imprisoned for the second time in Rome around 65 CE , where he wrote his second letter to Timothy, implying that his death was imminent (2Timothy 4:6-8), and was most likely martyred by Emperor Nero soon after.
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