If you had first taken Amoxicillin then you can add Azithromycin for more specific action towards a bacteria or if needed action towards some Atypical Bacteria. But not recommended to take initially both Antibiotics together.
Amoxicillin is a Broad spectrum Antibiotic while Azithromycin too. Amoxicillin deals G+ve Bacteria like Streptococcus Group A, Strep.Group C, Staphylococcus aureus, Bacillus diptheria, clostridium perfringens and spirochetes, G-ves like Neisseria species.
while Azithromycin deals with Atypical pneumonia caused by Legionella, Mycoplasma and chlamydial species along with strep.Group A and Group C, diptheria and Bordetulla species.
Amoxicillin efficient for treating G+ve Streps and Azithromycin efficient for treating Atypical pneumonia causing species.
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