How does lexapro and Wellbutrin work together?

My psychiatrist prescribed both at once.

AnswerNo they should not be taken together

why not?

Cymbalta and Lexapro have SIMILAR BUT NOT EXACTLY THE SAME mechanism of action [MEANING: these active ingredients illicit the same response and the enzymes attach to the same receptors (receivers) that prevents the serotinin from leaving the brain]. Cymbalta is an SNRI (Serotonin-Norepinephrine Reuptake Inhibitor) and Lexapro an SSRI (Selective-Serotonin Reuptake Inhibitor). Serotonin is "BELIEVED" (not certain) to lack from people who are clinically depressed and norepi has "significant" correlation with depression as well (LOW NOREPI in the brain results to DEPRESSION). Cymbalta and Lexapro both have positive responses in preventing the escape of SEROTONIN from the brain. The only difference is Cymbalta also inhibits/stops the escape of norepi from the brain and Lexapro ONLY prevents serotonin reuptake (removal from brain receptors). The probability of an overdose from these antidepressants is extremely high and can lead to 'serotonin syndrome; too much serotonin which can be fatal (nausea,coma then death). Because both drugs are preventing serotonin from leaving the brain and therefore an accumulation of serotonin in the brain receptors. Only your MD can determin the OPTIMUM strength (the highest strength of the meds. to achieve therapeutic goals without being toxic) of antidepressants. ALSO, if your MD can justify why he's giving you both meds to the insurance, it will be covered by insurance. This will definitely be reviewed prior to approval of claim. These types of drug interactions alerts your insurance and stops them from paying the claim. You may end up paying for either or both your meds out of pocket.