Who was the pilot in the first fatal plane crash?

The worst aviation disaster in terms of loss of human life would be the Tenerife airport disaster.

Due to poor visibility and misunderstood radio communications, two Boeing 747's collided on the runway at the Los Rodeos Airport in Tenerife Spain resulting in 583 deaths.

Captain Jacob Veldhuyzen van Zanten of KLM Flight 4805 was on a takeoff roll when it struck Pan Am flight 1736 piloted by Captain Victor Grubbs.