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The temperance movement in the United States was led by various influential figures, including Frances Willard, who was the president of the Women's Christian Temperance Union (WCTU), and Carry Nation, known for her radical actions against alcohol. Other prominent leaders included Anthony Comstock, who advocated for moral reform, and several religious leaders who emphasized the moral and social benefits of sobriety. The movement ultimately culminated in the passage of the 18th Amendment in 1919, establishing Prohibition.