Can co-codamol be taken with piriton?

Piriton and cocodamol can be taken together without drug interactions, but you should be aware that this combination may make you quite sleepy (since antihistamines sometimes make people drowsy and so can the codeine in the cocodamol). Probably best to try out the combination when you don't have any plans for the rest of the day, just in case is does make you sleepy.