Yes, John C. Calhoun was involved in the debates surrounding the Missouri Compromise of 1820. As a prominent political figure and proponent of states' rights, he opposed the compromise, arguing that it infringed upon the rights of slaveholding states. Calhoun believed that the federal government should not restrict the expansion of slavery into new territories, which he viewed as essential for the South's economic interests. His opposition highlighted the growing sectional tensions between the North and South over the issue of slavery.
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