What revenge can Macduff not get on Macbeth?

The massacre of an entire household is the revenge that Macduff cannot get on Macbeth.

Specifically, Macbeth orders the murder of all inhabitants of Macduff's castle. Macduff suspects that Macbeth's actions are headed in that direction. So he escapes death by fleeing across the border between Scotland and England. He leaves behind his possessions and household, including his wife and family. In England, Macduff learns that there are no Macduff survivors other than himself in the aftermath of Macbeth's raid.

Ultimately, Macduff fights and kills his sovereign. But Macbeth's Lady already dies at her own hands, Macbeth appears to have no descendants, and Macbeth's supporters desert to the combined armies of the invading English and disgruntled Scots.