Does polysporin have cortisone in it?

Polysporin does not contain cortisone. It is an over-the-counter antibiotic ointment that typically contains polymyxin B and bacitracin, which are used to prevent infection in minor cuts and scrapes. If you need a product with cortisone for inflammation or itching, you would need to look for a different medication specifically formulated with corticosteroids.