What will happen to protein digestion as medium of intestines is gradually rendered alkaline?

As the medium of the intestines becomes more alkaline, protein digestion may be affected because the activity of pepsin, the primary enzyme responsible for protein breakdown in the stomach, is optimal in an acidic environment. In the alkaline environment of the intestines, pancreatic enzymes like trypsin and chymotrypsin take over digestion. However, if the alkalinity is too high or not properly regulated, it could hinder the overall efficiency of protein digestion and absorption, potentially leading to malabsorption issues.