Is Artwork copyrighted example If One uses American Gothic by Grant Wood as inspiration changes faces clothing and some scenary could one be sued?

No not true, American Gothic is already in the public domain

Grant Wood's American Gothic was first published in 1930 but fell into the public domain in the United States in 1958. Wood's estate filed a renewal application in 1980, more than two decades after the one-year renewal window had closed at the end of 1958, but it was too late, so the painting remained in the public domain.