What happens when you take methadone with suboxone in your system?

It probably depends on your usage habits. For instance, you likely would not get sick if you were to take 1 or 2 10mg hydrocodone after a dentist's appointment and then take suboxone a week later. However, since opioids can accumulate in your body, if you have had a steady habit for a long while it will take longer for them to purge out of your system.