Why did my Cymbalta stop working when i quit smoking?

Cymbalta (duloxetine) is an antidepressant that can be influenced by various factors, including lifestyle changes like quitting smoking. Smoking can affect the metabolism of certain medications, potentially enhancing their effects. When you quit smoking, your body may metabolize Cymbalta differently, leading to a decrease in its effectiveness. Additionally, withdrawal from nicotine can impact mood and anxiety levels, which might also contribute to the perception that Cymbalta is no longer working.