How many miles is it from Pittsburgh to Harrisburg?

250 miles taking this route:

1. Take I-376 EAST, from New Castle, to I-76 Pennsylvania TURNPIKE (toll road) to Ohio and HARRISBURG off EXIT 26. Follow signs to I-76 EAST to HARRISBURG.
2. Take I-76 EAST, on the PENNSYLVANIA TURNPIKE (toll road), to Harrisburg.