Can caffeine form Hydrogen bond

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1045411

2026-08-06 06:55

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I looked at the structure and it has two Carbonyl groups, C=O, so perhaps that oxygen can hydrogen bond with hydrogen on water, It also has three methyl groups, CH3, which are nonpolar, so I do not know how soluble caffeine is in water, but it surely is in coffee which is mostly water.

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