Can you use key bob to unlock your 03 escape while it is running with the doors locked?

No, you cannot use the key fob to unlock a 2003 Ford Escape while it is running and the doors are locked. The key fob is designed to unlock the doors only when the vehicle is in a locked state and doesn't override the locking mechanism when the engine is running. You would need to manually unlock the door or use a spare key to gain access.