Why does cortisone shot cause facial flushing?

Cortisone shots can cause facial flushing due to the drug's effects on blood vessels. Cortisone, a corticosteroid, can lead to vasodilation, which increases blood flow to the skin, resulting in a flushed appearance. Additionally, the body's response to the injection may trigger a temporary inflammatory reaction, further contributing to the flushing. This side effect is typically short-lived and resolves as the body adjusts to the medication.