What does the supremacy clause mean in Article 6 of the Constitution?

The Supremacy Clause (Article VI, Clause 2) stipulates that the Constitution is the absolute final authority in the United States. In practical terms, it means that no other law or legal entity can override the Constitution; in addition, it also means that legally-derived powers granted by the Constitution have similar supreme authority over any other claim of authority in the U.S.

From a functional standpoint, the Supremacy Clause made clear that State laws are subservient the Federal Laws.