What affect will happen on the mass of a substance if taken on moon?

This is a trick question! The mass of a substance does not change no matter where it is, even when it is weightless in space. The mass says in a way how much "stuff" there is, which does not depend on where it is.

The "weight" of a substance is how heavy it is, how much force it puts on the ground. The weight says how hard it is to lift. The weight of a substance will only be 1/6 as much on the moon because the moon has less gravity than the earth, since the gravity of something depends on how big it is and the moon is smaller than the earth.